27 Aug Do Weight Loss Injections Really Work?

Last year the UK press recently announced that high street chemists have been given approval to sell Wegovy, the controversial weight loss injection. This followed reports in 2022 of the ‘game-changing weight loss injection‘ to be offered on the NHS. It seems too good to be true. Could a simple injection be all you need to get your weight challenges under control?

Our weight loss clinic has been inundated with calls from people asking if we offer “diet injections” or the “skinny jab”. No doubt as a result of extensive media coverage. Newspapers and magazines have reported that celebrities like Elon Musk and Kim Kardashian have lost weight using Ozempic, the same drug as Wegovy. Weight loss jabs like Ozempic have truly taken the world by storm.

So do weight loss injections really work? And should you consider getting one? Here’s what you need to know about the weight loss jabs everyone’s talking about.

If you’d like to find out how we can help you overcome your weight challenges naturally, achieve your desired weight and maintain it long term, we invite you to book a complimentary call with a member of our team to learn more.

WHAT IS THE WEIGHT LOSS INJECTION?

Let’s start by looking at what’s actually in the syringe. Both of the most popular weight loss medications, Wegovy and Ozempic, are brand names for the drug Semaglutide. The difference between Wegovy and Ozempic is the dose. Wegovy is available up to 2.4mg whereas Ozempic is available up to 1mg.

Semaglutide is a medication originally used to treat type 2 diabetes. It belongs to a class of drugs called GLP-1 receptor agonists. These drugs work by mimicking the effects of a hormone called glucagon-like peptide-1 (GLP-1) in the body.

HOW DO WEIGHT LOSS INJECTIONS WORK?

Semaglutide works by increasing the release of insulin from the pancreas and reducing the amount of glucose produced by the liver. This helps to lower blood sugar levels in people with type 2 diabetes.

When it comes to losing weight, GLP-1 agonists can promote weight loss in a number of ways. One of the main ways is by reducing appetite. These drugs act on receptors in the brain that control hunger and satiety. This leads to an increased feeling of fullness and reduced appetite.

GLP-1 agonists also slow down the emptying of the stomach. This can help people feel fuller for longer after eating and reduce the urge to eat again soon after a meal.

Finally, GLP-1 agonists have been shown to boost the metabolism and increase energy expenditure. There are currently five GLP-1 receptor agonists currently available in the UK according to NICE.

A new study suggests that Ozempic may work differently than previously thought. Researchers now think it also impacts users’ metabolism. The study, led by Professor Donal O’Shea, involved 30 people with obesity and obstructive sleep apnea taking glucagon-like peptide 1 analogs. Participants experienced weight loss and increased metabolism, with those having a sluggish metabolism at the start benefiting the most.

SO, WHAT’S THE PROBLEM?

We have two primary concerns about this weight loss injection, both of which we’ll go on to discuss in more detail: Firstly, an injection alone does nothing to get to the root cause of why people have gained weight. Not tackling the root cause is highly likely to result in weight regain. Secondly, the list of potential side effects are concerning.

WEIGHT LOSS INJECTION SIDE EFFECTS

Not only do weight loss injections do little to ensure long term weight loss, they also come with some concerning side effects.

Common side effects listed on the Wegovy’s website include: nausea, diarrhea, vomiting, constipation, stomach pain, headache, tiredness (fatigue), upset stomach, dizziness, feeling bloated, belching, gas, stomach flu, heartburn.

So far, unpleasant, but not life threatening. However, we then come on to the more serious concerns. I have lifted the following text directly from Wegovy’s website:

Wegovy™ may cause serious side effects, including: Possible thyroid tumours, including cancer. Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rodents, Wegovy™ and medicines that work like Wegovy™ caused thyroid tumors, including thyroid cancer. It is not known if Wegovy™ will cause thyroid tumours or a type of thyroid cancer called medullary thyroid carcinoma in people.

A simple interpretation: rodents who were given these medications got cancer. You might too but we don’t actually know for sure. A full list of side effects can be found here.

Read our post on the side effects of weight loss injections here.

Recent research shows that around 30% of people discontinue taking the weight loss drugs Wegovy and Saxenda before reaching their target dose, potentially due to the side effects, with over half quitting within 12 weeks. Younger adults and those with higher barriers to care were least likely to adhere to the regimen.

WILL YOU PUT THE WEIGHT BACK ON?

If you’re willing to risk those sorts of side effects, you’d be hoping for a long term solution. Sadly though, the chances are you will regain weight after using these jabs. Especially if you don’t tackle the underlying issues that caused your weight gain in the first place.

GLP1 agonists like Ozempic, Wegovy and Saxenda have only having been made widely available for weight loss relatively recently. Despite this, there are already numerous reports of people regaining weight after coming off the drugs. Novo Nordisk are the makers of Wegovy and Ozempic. The company’s senior vice president of global drug discovery, Karin Conde-Knape, has said that people have to keep taking their drug to keep the weight off. CNBC reported that Conde-Knape said some individuals may actually gain more weight after stopping these drugs than they initially lost.

Individuals such as TikTok creator Remi Bader have spoken openly about their weight regain after using Ozempic. Remi claims that she “gained double the weight back” and shared that coming off the drug made her binge eating “so much worse”.

THE RISE OF FAKE OZEMPIC

Aside from the side effects and long-term impact of Ozempic, there are other risks around the rise of fake weight-loss injections. The World Health Organization (WHO) has issued a global alert about fake Ozempic. Counterfeit versions of the drug, which contains semaglutide, have been seized in the UK, US, and Brazil. The WHO warns that these fake medications may not contain the active ingredient or, even worse, could include harmful substances, posing significant health risks. While more and more people are buying Ozempic and other weight loss jabs online and not obtaining access through official doctors, this poses an increasing additional risk to health.

WHAT ARE THE DIFFERENT WEIGHT LOSS INJECTIONS?

We have looked at the two most discussed weight loss injections, Wegovy and Ozempic, both of which contain the GLP-1 agonist Semaglutide. But what other weight loss injections are there?

Saxenda (liraglutide) is another GLP-1 medication and is FDA-approved for weight loss. Like Semaglutide, it works by reducing appetite and increasing feelings of fullness.

Contrave (naltrexone HCl and bupropion HCl) injections combine two medications that work to reduce appetite and cravings for food. Naltrexone was initially developed to treat addiction to opioids.

Qsymia (phentermine and topiramate) injections are also a combination of two medications. They work to reduce appetite and increase feelings of fullness. Phentermine is a stimulant and was withdrawn from the market in the UK in 2000. Qsymia can cause serious side effects including birth defects and suicidal thoughts and actions.

Belviq (lorcaserin) worked by affecting the serotonin receptors in the brain, which could reduce appetite and facilitate weight loss. In February 2020, the FDA requested that the manufacturer of lorcaserin withdraw the drug from the US market because a clinical trial showed an increased occurrence of cancer.

WHAT ARE THE DIFFERENCES BETWEEN THE MAIN WEIGHT LOSS INJECTIONS?

Ozempic and Wegovy both contain the drug Semaglutide, which is a synthetic version of a hormone called GLP-1. These are the two jabs being widely discussed in the press at present.

The difference between the two is the dosage amounts. Ozempic is available in doses of 0.25mg, 0.5mg, and 1mg, while Wegovy is available in higher doses. As well as doses of 0.25mg, 0.5mg, 1mg, Wegovy goes up to 1.7mg and 2.4mg (the maximum dose). The recommended starting dose for both medications is typically the lowest available dose, with the dosage gradually increased over time. However, you should always follow your doctors guidance around dosing.

Ozempic was approved by the FDA in 2017 for use in adults with type 2 diabetes, and later for use in adults without diabetes for weight loss. Wegovy, on the other hand, was only recently approved by the FDA in June 2021 specifically for weight loss in adults who are overweight or obese.

Both medications are given by injection, but they have different injection devices. Ozempic is administered once a week. Wegovy is administered once a week for the first month and then once every four weeks thereafter. 

Both medications can cause similar side effects as mentioned above. The severity and frequency of side effects can vary between individuals and may depend on the dosage.

WHAT RESEARCH HAS BEEN DONE INTO WEIGHT LOSS INJECTIONS?

There have been several types of weight loss injections that have been researched. Here’s a brief overview of the most popular ones:

Wegovy and Ozempic (Semaglutide) – This injectable medication is a GLP-1 agonist and has been found to be effective in clinical trials for weight loss. It is currently undergoing review by the FDA for approval for weight loss.

Saxenda (Liraglutide) – This is another GLP-1 drug, which regulates appetite and digestion. It has been approved by the FDA for use in adults with a BMI of 30 or greater or for those with a BMI of 27 or greater who also have at least one weight-related health condition, such as high blood pressure, type 2 diabetes, or high cholesterol.

Human chorionic gonadotropin (HCG) – This hormone is sometimes used in combination with a very low-calorie diet to promote weight loss. However, there is little evidence to support its effectiveness, and the FDA has not approved it yet for weight loss purposes.

B12 injections – While not specifically designed for weight loss, some people use vitamin B12 injections to boost their energy levels and metabolism, which can indirectly aid in weight loss efforts.

SO SHOULD YOU GET A WEIGHT LOSS INJECTION?

If you care about your body and want to lose weight safely and in a way that supports your wider health, think twice before getting a weight loss injection. These injections come with risks. Weight loss medications in general do not have a good safety record. One research paper found that 25 anti-obesity medications were withdrawn between 1964 and 2009 due to safety concerns.

Making changes to your diet and lifestyle can help you lose weight in a safe and sustainable way, with long-term results and no risks from drugs or surgeries. Working with a dedicated nutritionist means that you can benefit from tailored health, diet and lifestyle guidance along with supportive accountability.

WHAT ARE THE ALTERNATIVES?

If you’re looking for something to support your weight loss, you may wish to consider supplements. Of course, optimising your diet and lifestyle and exercising regularly comes first. However, certain quality supplements can support your efforts. Green tea extract and capsaicin supplements have been shown to speed up the metabolic rate. Glucomannan is a fibre supplement that swells in the stomach and can reduce appetite. CLA is a well researched dietary fat that works in various ways to support fat loss. You may wish to explore these naturally occurring compounds as an alternative to a fat burning injection. Read our article on evidence based weight loss supplements for more.

WE CAN HELP YOU LOSE WEIGHT SAFELY AND EFFECTIVELY

If you’re looking to lose weight, there really is no substitute for a holistic approach to weight loss. We can help you overcome your weight challenges, reach your ideal weight and maintain it long term. Book yourself in for a complimentary 25 mintue call or contact us and a member of our team will be in touch soon. We can talk through your challenges and explore whether one of our Intelligent Weight Loss programmes is right for you.